DS-01™
Daily Synbiotic

For Gastrointestinal + Whole-body Health

Our proprietary formulation contains 24 clinically and scientifically studied, broad-spectrum strains to support systemic health.

53.6 Billion AFU

2-in-1 ViaCap® Delivery Technology

Our capsule-in-capsule design shields against digestion, ensuring* viability of live probiotics through the end of the small intestine for delivery into the colon.


*To evaluate the survival of our probiotics, we use a Simulator of the Human Intestinal Microbial Ecosystem—the closest system developed to model digestion and the gut.

Sustainable Refill System 2.0

Our packaging and materials are engineered to be gentler on our Earth. Your Welcome Kit includes a free travel vial, and refills arrive monthly in a compostable biofilm.

Start Now$49.99 / month
  • Free US shipping. International flat-rate.
  • Skip or cancel any time.
  • 30 day risk-free guarantee.

Promotes digestive health (to support healthy regularity and ease of bloating)*

Reinforces healthy stool hydration and ease of evacuation*

Supports gut ease from occasional gastrointestinal discomfort associated with increased intestinal transit time*

Gut Barrier Integrity

Maintains healthy gut barrier function and integrity*

Reinforces healthy tight junction in vitro*

Supports healthy gut barrier integrity from ethanol- and endotoxin-induced (lipopolysaccharide) permeability in vitro*

Gut Immune Function

Supports healthy gut immune function and 'cross-talk' between immune and intestinal cells*

Maintains healthy immunological responses in the gastrointestinal tract*

Supports production of short-chain fatty acids*

Cardiovascular Health

Promotes heart health*

Maintains blood cholesterol levels already in the normal range*

Supports healthy intestinal recycling of cholesterol and bile*

Dermatological Health

Promotes healthy skin*

Reinforces healthy gut-skin axis*

Supports folate (vitamin B9) production via intestinal synthesis of bioactive forms of folate*

Supports synthesis of vitamin B12 in vitro*

Benefits beyond
your gut.

Formulated with strains that support:

Digestive Health
Digestive Health

Promotes digestive health (to support healthy regularity and ease of bloating)*

Reinforces healthy stool hydration and ease of evacuation*

Supports gut ease from occasional gastrointestinal discomfort associated with increased intestinal transit time*

Gut Barrier Integrity
Gut Barrier Integrity

Maintains healthy gut barrier function and integrity*

Reinforces healthy tight junction in vitro*

Supports healthy gut barrier integrity from ethanol- and endotoxin-induced (lipopolysaccharide) permeability in vitro*

Gut Immune Function
Gut Immune Function

Supports healthy gut immune function and 'cross-talk' between immune and intestinal cells*

Maintains healthy immunological responses in the gastrointestinal tract*

Supports production of short-chain fatty acids*

Cardiovascular Health
Cardiovascular Health

Promotes heart health*

Maintains blood cholesterol levels already in the normal range*

Supports healthy intestinal recycling of cholesterol and bile*

Dermatological Health
Dermatological Health

Promotes healthy skin*

Reinforces healthy gut-skin axis*

Micronutrient Synthesis
Micronutrient Synthesis

Supports folate (vitamin B9) production via intestinal synthesis of bioactive forms of folate*

Supports synthesis of vitamin B12 in vitro*

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Engineered to
survive

ViaCap® Delivery Technology

Our 2-in-1 nested capsule safeguards viability through digestion for delivery of an average of 100% of our probiotic starting dose to your colon. The outer capsule also serves as a barrier to oxygen, moisture, and heat—no refrigeration necessary.

Probiotic Inner Capsule

Our probiotic formulation consists of clinically and scientifically studied strains characterized at academic institutions and research partners in Italy, Spain, Belgium, US, and Japan. It is biofermented in Europe, and is not of animal or soil origin.

Prebiotic Outer Capsule

Our prebiotic formulation consists of punicalagins concentrated from Indian pomegranate—biotransformed by gut microbes into powerful metabolites for human health.

Formulation

53.6 Billion AFU
No refrigeration required.

Probiotic Inner Capsule
Probiotic Inner Capsule

Our probiotic formulation consists of clinically and scientifically studied strains characterized at academic institutions and research partners in Italy, Spain, Belgium, US, and Japan. It is biofermented in Europe, and is not of animal or soil origin.

Digestive Health / Gut Immunity / Gut Barrier Integrity Probiotic Blend37.0 Billion AFU

Bifidobacterium longum SD-BB536-JP 

Bifidobacterium breve SD-BR3-IT 

Lactiplantibacillus plantarum SD-LP1-IT 

Lacticaseibacillus rhamnosus SD-LR6-IT 

Lacticaseibacillus rhamnosus HRVD113-US 

Bifidobacterium infantis SD-M63-JP 

Bifidobacterium lactis SD-BS5-IT 

Bifidobacterium lactis HRVD524-US 

Lactobacillus crispatus SD-LCR01-IT 

Lacticaseibacillus casei HRVD300-US 

Bifidobacterium breve HRVD521-US 

Bifidobacterium longum HRVD90b-US 

Bifidobacterium lactis SD150-BE 

Limosilactobacillus fermentum SD-LF8-IT 

Lacticaseibacillus rhamnosus SD-GG-BE 

Limosilactobacillus reuteri RD830-FR

Dermatological Health Probiotic Blend3.30 Billion AFU

Ligilactobacillus salivarius SD-LS1-IT

Bifidobacterium lactis SD-CECT8145-SP

Bifidobacterium longum SD-CECT7347-SP

Lacticaseibacillus casei SD-CECT9104-SP

Cardiovascular Health Probiotic Blend5.25 Billion AFU

Lactiplantibacillus plantarum SD-LPLDL-UK

Bifidobacterium lactis SD-MB2409-IT

Micronutrient Synthesis Probiotic Blend8.05 Billion AFU

Bifidobacterium adolescentis SD-BA5-IT

Limosilactobacillus reuteri SD-LRE2-IT

Microbiota-Accessible Polyphenolic Precursors™️ [MAPP]400mg

Indian Pomegranate [whole fruit] (Punica granatum) (>40% Polyphenolic + Phenolic Bioactives)

Prebiotic Outer Capsule
Prebiotic Outer Capsule

Our prebiotic formulation consists of punicalagins concentrated from Indian pomegranate—biotransformed by gut microbes into powerful metabolites for human health.

Other Ingredients

Acid-Resistant Vegan Outer [chlorophyllin] and Inner Capsules [hypromellose, fermented gellan gum, water] 

Organic rice fiber 

Organic rice extract blend

Digestive Health / Gut Immunity / Gut Barrier Integrity Probiotic Blend

37.0 Billion AFU

Bifidobacterium longum SD-BB536-JP 

Bifidobacterium breve SD-BR3-IT 

Lactiplantibacillus plantarum SD-LP1-IT 

Lacticaseibacillus rhamnosus SD-LR6-IT 

Lacticaseibacillus rhamnosus HRVD113-US 

Bifidobacterium infantis SD-M63-JP 

Bifidobacterium lactis SD-BS5-IT 

Bifidobacterium lactis HRVD524-US 

Lactobacillus crispatus SD-LCR01-IT 

Lacticaseibacillus casei HRVD300-US 

Bifidobacterium breve HRVD521-US 

Bifidobacterium longum HRVD90b-US 

Bifidobacterium lactis SD150-BE 

Limosilactobacillus fermentum SD-LF8-IT 

Lacticaseibacillus rhamnosus SD-GG-BE 

Limosilactobacillus reuteri RD830-FR

Dermatological Health Probiotic Blend

3.30 Billion AFU

Ligilactobacillus salivarius SD-LS1-IT

Bifidobacterium lactis SD-CECT8145-SP

Bifidobacterium longum SD-CECT7347-SP

Lacticaseibacillus casei SD-CECT9104-SP

Cardiovascular Health Probiotic Blend

5.25 Billion AFU

Lactiplantibacillus plantarum SD-LPLDL-UK

Bifidobacterium lactis SD-MB2409-IT

Micronutrient Synthesis Probiotic Blend

8.05 Billion AFU

Bifidobacterium adolescentis SD-BA5-IT

Limosilactobacillus reuteri SD-LRE2-IT

Microbiota-Accessible Polyphenolic Precursors™️ [MAPP]

400mg

Indian Pomegranate [whole fruit] (Punica granatum) (>40% Polyphenolic + Phenolic Bioactives)

Other Ingredients

Acid-Resistant Vegan Outer [chlorophyllin] and Inner Capsules [hypromellose, fermented gellan gum, water] 

Organic rice fiber 

Organic rice extract blend

Vegan
Vegan
Gluten-Free
Gluten-Free
Dairy-Free
Dairy-Free
Soy-Free
Soy-Free
Nut-Free
Nut-Free
Shellfish-Free
Shellfish-Free
Sesame-Free
Sesame-Free
Glyphosphate/AMPA-Free
Glyphosphate/AMPA-Free
Corn-Free
Corn-Free
No Binders
No Binders
No Preservatives
No Preservatives
Prop. 65 Compliant
Prop. 65 Compliant

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha

Not all probiotics are created equal.

yogurt

Not all probiotics are created equal.

kombucha
DS-01™OTC ProbioticsFermented FoodsFermented
Beverages
Proprietary ViaCap® delivery technology
Broad spectrum formulation with multiple strains from within species (24 strains)Rare
Research-derived potencies (53.6B AFU)Rare
Systemic benefits beyond the gutRare
Produces specific beneficial SCFA (short-chain fatty acids)UnknownUnknownUnknown
Supports expression of tight junction proteins in gut barrier cellsUnknownUnknownUnknown
100% survival through simulated digestion* (stomach acid, bile salts, and digestive enzymes)
Non-fermenting prebiotics compatible with FODMAPS dietRareRare
No skip-lot testing for over 400 allergens and pesticide residues at 3rd party accredited laboratoriesUnknown
Active Fluorescent Units (AFU) testing via flow cytometry for precise enumeration of viable cells in a multi-strain formulationUnknown
Precision release at top of gastrointestinal tractUnknown
Whole-genome testing via shotgun sequencing of microbial DNAUnknown
Oxford nanopore fully assembled closed genome sequencing for strain characterization
Heat, moisture and light protected—no refrigeration requiredRareN/AN/A
Heat testing to ensure viability through shipping conditionsRare
Proprietary ViaCap® delivery technology
Broad spectrum formulation with multiple strains from within species (24 strains)
Research-derived potencies (53.6B AFU)
Systemic benefits beyond the gut
Produces specific beneficial SFCA (short-chain fatty acids)
Supports expression of tight junction proteins in gut barrier cells
100% survival through simulated digestion* (stomach acid, bile salts, and digestive enzymes)
Non-fermenting prebiotics compatible with FODMAPS diet
No skip-lot testing for over 400 allergens and pesticide residues at 3rd party accredited laboratories
Active Fluorescent Units (AFU) testing via flow cytometry for precise enumeration of viable cells in a multi-strain formulation
Precision release at top of gastrointestinal tract
Whole-genome testing via shotgun sequencing of microbial DNA
Oxford nanopore fully assembled closed genome sequencing for strain characterization
Heat, moisture and light protected—no refrigeration required
Heat testing to ensure viability through shipping conditions

*To evaluate the survival of our probiotics, we use a Simulator of the Human Intestinal Microbial Ecosystem—the closest system developed to model digestion and the gut.

A new standard in probiotics.

Survivability

Probiotics are most effective when they make it to your colon, alive. Our ViaCap®️ technology ensures bacteria survive and stay viable through digestion. Bonus: no synthetic or chemical coating and no refrigeration required.

Biofermentation

How bacteria are cultured impacts their viability. We optimize our biofermentation for pH, temperature, and 28 other critical growth factors. Our mediums contain no meat or dairy.

Testing

We do extensive no-skip-lot testing at each step of the manufacturing process as well as on the final product. With 50+ quality assurance and quality control (QA/QC) checkpoints, we monitor purity under both US and European protocols (including cGMP + HACCP) throughout the production cycle.

Survivability
Testing
Biofermentation
Biofermentation
Survivability
Testing

Survivability

Probiotics are most effective when they make it to your colon, alive. Our ViaCap®️ technology ensures bacteria survive and stay viable through digestion. Bonus: no synthetic or chemical coating and no refrigeration required.

Survivability
Biofermentation
Testing

Biofermentation

How bacteria are cultured impacts their viability. We optimize our biofermentation for pH, temperature, and 28 other critical growth factors. Our mediums contain no meat or dairy.

Survivability
Testing
Biofermentation

Testing

We do extensive no-skip-lot testing at each step of the manufacturing process as well as on the final product. With 50+ quality assurance and quality control (QA/QC) checkpoints, we monitor purity under both US and European protocols (including cGMP + HACCP) throughout the production cycle.

Sustainably delivered, monthly.

Each component of our refill system is designed to protect your DS-01™ and be gentler on our Earth.

Start Now $49.99 / month

Month 1 — Welcome Kit

  • Refillable Glass Jar

  • Glass Travel Vial

  • 30 Day Supply (60 Capsules)

Month 2 — Sustainable Refills

  • 30 Day Supply (60 Capsules)

For the curious.

How do I take DS-01™?

Adults—take 2 capsules daily, all at once. Preferably on an empty stomach to limit exposure to digestive enzymes and bile salts. However, you know your body best—if it’s more comfortable for you to take with food, please feel free to do so.

Why should I take DS-01™?

You are home to a community of trillions of microorganisms, including 38,000,000,000,000 bacteria that live in and on you. They perform critical functions like digesting food, managing inflammation, and synthesizing key vitamins, metabolites and neurotransmitters. This is the microbiome.

However, modern living disturbed the balance of this ecosystem. Antibiotic overuse combined with alcohol, sugar, tobacco, disrupted sleep, city-living, decreased breastfeeding, stress, poor diet, and other environmental factors, have depleted the diversity and richness of our microbiomes and impacted our health.

This goes beyond simple digestive issues. The first of its kind, our DS-01™ includes clinically and scientifically studied probiotic strains that deliver core benefits to the gastrointestinal system which, in turn, influence systemic health.

What does the DS-01™ do?

The DS-01™ contains probiotic strains that have been clinically and scientifically studied to provide benefits around gastrointestinal function, skin health, heart health, gut immune function, gut barrier integrity, and micronutrient synthesis. You may access the strain-specific clinical studies associated with each benefit in our Reference Library.

When will I feel something?

Everyone’s body is different, and the benefits you may ‘feel’ (ease of bloating, more regular bowel movements) are often just the most visceral ones.

Many people feel results in as a little as 24-48 hours due to localized benefits like digestive health support. Other longer term benefits like cardiovascular health and gut immune function may take longer, or you may not notice anything at all. That’s completely normal. As long as you continue your daily intake, those beneficial microbes are doing their work inside to program, sustain, and enhance your health.

Who should take the DS-01™?

The DS-01™ is meant for humans ages 18+.

Is DS-01™ compatible with my diet or dietary restrictions?

DS-01™ is free from: Dairy • Gluten • Soy • GMOs • Nuts • Shellfish • Sesame • Glyphosate/AMPA • Binders • Preservatives • 14 classes of allergens defined by European Food and Safety Authority (EFSA)

It adheres to the following diets: Vegan • Vegetarian • Ketogenic • Gluten-Free • Intermittent Fasting

Can I take this with other supplements? What about medications?

DS-01™ is safe to take with other supplements.

There are no known contraindications with DS-01™ and any over the counter or prescription medications, though we encourage you to double check with your physician before adding our product to your regimen.

Is DS-01™ safe to take while I'm pregnant or breastfeeding?

Yes, DS-01™ is safe to take during pregnancy and while breastfeeding, but as with all new changes during this time, we suggest that you also speak with your physician.

Fun company fact: Seed Co-Founders Ara and Raja were introduced when Ara was pregnant. Her journey through pregnancy and breastfeeding (with Raja’s guidance and education) inspired their collaborative vision for Seed.

Do I need to refrigerate my DS-01™?

The short answer is no. No refrigeration necessary.

It’s a question we receive often, since many probiotics are sold in the refrigerated section at grocery stores and retailers. However, contrary to perishable food products, refrigeration doesn’t mean ‘freshness’ or superiority. In fact, if a probiotic does not survive at ambient temperature outside of the refrigerator, it can reflect weak stability of the product, low viable organism count, or inadequate overages in formulation.

Our probiotic strains are stable for 18 months at ambient temperature (up to 79° F). If your home is consistently warmer for extended periods, consider refrigerating in an oxygen tight container to avoid exposure to moisture.

What does my subscription to DS-01™ include?

Your monthly subscription includes a 30-day supply of DS-01™. Your first month’s shipment is your Welcome Kit. It includes a reusable glass jar holding your first month’s supply, some Seed reading materials, and a complimentary travel vial that holds a week’s worth of your DS-01™, so you never miss a day on the go.

Do I have to sign up for a subscription?

Yes. We believe that probiotics and prebiotics, alongside diet, nutrition, exercise, and lifestyle, are cornerstone tools to building foundational health. Clinical research shows that continuous, daily intake is the best way to get the most out of your synbiotic. By signing up for a subscription, you’ll easily be able to build DS-01™ into your routine.

But we want you to feel good about what you’re taking. That’s why we want you to try DS-01™, risk-free for 30 days. You may also reschedule or cancel your subscription easily from your account at any time.

What is your 30 day risk-free guarantee?

If for any reason you are not satisfied with your purchase, you may request a refund within 30 days of delivery of your first order. We’ll refund you for the full cost of the product less shipping, VAT, or duties—no questions asked. For all subsequent shipments, you may reschedule or cancel at any time in your account.

Do you ship internationally?

Yes—find out more at seed.com/entire-world

Is climate change real?

Yes.

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